Imphepho has many uses. The smoke of the herb is used as a sacred incense or smudge used to call the ancestors in and invoke trance states, cleanse energy and as an offering when praying. The smoke is also sedative. Traditionally Imphepho is burned on a potsherd when offered to the ancestors. Medicinal uses of the plant include antiseptics, insecticides, anti-microbial, anti-inflammatory and pain relieving (analgesic). The parts of the plant used are mainly the leaves, stems and flowers and sometimes the roots.